• 
  Sao Paolo – Flamengo-RJ

  6 November

• 
  Gremio-RS – Cruzeiro-MG

  6 November

• 
  Atletico-MG – Bahia

  6 November

• 
  Botafogo-RJ – Vasco

  5 November

• 
  RB – Corinthians

  5 November

• 
  Vitoria-BA – Inter-RS

  5 November

• 
  Sport Recife – Juventude

  5 November

• 
  Manchester – Dortmund

  5 November

• 
  Brügge – Barcelona

  5 November

• 
  Marseille – Atalanta

  5 November

• 
  Newcastle United – Athletic

  5 November

• 
  Inter – Qairat

  5 November

• 
  Ajax – Galatasaray

  5 November

• 
  Benfica – Leverkusen

  5 November

• 
  Qarabag – Chelsea

  5 November

• 
  Paphos – Villarreal

  5 November

• 
  Crystal Palace – AZ

  6 November

• 
  Lincoln – Rijeka

  6 November

• 
  Rayo Vallecano – Lech

  6 November

• 
  Rapid Wien – U Craiova

  6 November

• 
  Dynamo Kiew – Zrinjski

  6 November

• 
  Shelbourne – Drita

  6 November

• 
  Skendija – Jagiellonia

  6 November

• 
  Häcken – Straßburg

  6 November

• 
  Lausanne – Omonia

  6 November

• 
  Schachtar – Breidablik

  6 November

• 
  Mainz 05 – Florenz

  6 November

• 
  AEK Larnaka – Aberdeen

  6 November

• 
  Noah – Sigma

  6 November

• 
  Samsunspor – Hamrun

  6 November

• 
  AEK – Shamrock Rovers

  6 November

• 
  Sparta Prag – Rakow

  6 November

• 
  Celje – Legia Warschau

  6 November

• 
  KuPS – Slovan Bratislava

  6 November

• 
  Rangers – Roma

  6 November

• 
  Aston Villa – Maccabi

  6 November

• 
  Stuttgart – Feyenoord

  6 November

• 
  Real Betis – Lyon

  6 November

• 
  PAOK – Young Boys

  6 November

• 
  Braga – Genk

  6 November

• 
  Ferencvaros – Ludogorez

  6 November

• 
  Bologna – Brann

  6 November

• 
  Viktoria – Fenerbahce

  6 November

• 
  Sturm Graz – Nottingham

  6 November

• 
  Malmö – Panathinaikos

  6 November

• 
  RB Salzburg – Go

  6 November

• 
  Dinamo Zagreb – Celta

  6 November

• 
  Roter Stern – Lille

  6 November

• 
  Midtjylland – Celtic

  6 November

• 
  Nizza – Freiburg

  6 November