• 
  Gimnasia y Esgrima LP – Estudiantes

  8 December

• 
  Atalanta – Chelsea

  9 December

• 
  AS Monaco – Galatasaray

  9 December

• 
  Inter – Liverpool

  9 December

• 
  Barcelona – Eintracht

  9 December

• 
  Union – Marseille

  9 December

• 
  Tottenham – Slavia

  9 December

• 
  PSV – Atletico Madrid

  9 December

• 
  Bayern Munich – Sporting

  9 December

• 
  Kairat – Olympiacos

  9 December

• 
  Santa Fe – Atl

  9 December

• 
  Ind Medellin – Atletico

  8 December

• 
  America de Cali – Atletico

  8 December

• 
  Deportes Tolima – Fortaleza

  8 December

• 
  Emelec – Macara

  9 December

• 
  Wolverhampton – Manchester

  8 December

• 
  Torino – Milan

  8 December

• 
  Udinese – Genoa

  8 December

• 
  Pisa – Parma

  8 December

• 
  Guimaraes – Gil Vicente

  8 December

• 
  Botosani – Rapid

  8 December

• 
  UTA Arad – Petrolul

  8 December

• 
  Osasuna – Levante

  8 December

• 
  Besiktas – Gaziantep

  8 December

• 
  Alanyaspor – Antalyaspor

  8 December

• 
  Poltava – Epitsentr

  8 December

• 
  Igokea – Dubai

  8 December

• 
  Johor DT – Shanghai Port

  9 December

• 
  Buriram Utd – Gangwon

  9 December

• 
  Machida Zelvia – Ulsan

  9 December

• 
  Vissel Kobe – Chengdu

  9 December

• 
  SE Melbourne Phoenix – Tasmania

  10 December

• 
  Sumqayit – Imisli

  9 December

• 
  Araz-Naxcivan – Kapaz

  9 December

• 
  Sabah – Neftchi

  8 December

• 
  Botev Vratsa – Montana

  9 December

• 
  Ludogorets – Slavia

  8 December

• 
  CSKA 1948 – Dobrudzha

  8 December

• 
  Beroe – Balkan

  8 December

• 
  Lube – Montpellier

  9 December

• 
  Oostende – Malaga

  9 December

• 
  Elan Chalon – Alba

  9 December

• 
  Karditsas – Mersin

  9 December

• 
  Bnei Herzliya – Tofas

  9 December

• 
  LKPS Lublin – Halkbank

  9 December

• 
  Sabah – Nymburk

  9 December

• 
  Sheffield Utd – Norwich

  9 December

• 
  Watford – Sheffield

  9 December

• 
  Southampton – West

  9 December

• 
  Colchester Utd –

  9 December